||This document provides environmental, health, and safety guidance to researchers working with engineered nanomaterials in Stanford University laboratories. Stanford University has been at the forefront of nanomaterial safety (see report ID 453) among California nanomaterial users. This document supplements Stanford’s existing chemical hygiene plan and laboratory safety toolkit. Specifically, it addresses engineering controls, selection of nanomaterials, safety equipment, hygiene, labeling and signage, cleaning, transporting, a buddy system, personal protective equipment, training, standard operating procedures, and consultation. The document also describes the risk of exposure for various nanomaterial activity types and the primary control measures to be used for each type of activity.