||This NASA guideline dictates the procedural requirements for handling nanomaterials in NASA’s Ames research laboratory. Compliance with these requirements is mandatory. Procedures include weighing dry, loose nanoparticles in a fume hood or glove box, manipulating quantities of dry, loose nanoparticles only in fume hoods or glove boxes unless a job hazardous analysis is performed, wearing safety goggles and gloves, and avoiding skin contact. Unique to NASA is the handling of lunar dust for grinding and milling. A job hazard analysis and personal protective equipment analysis must be undertook before manipulating quantities of dry dust. Wiping of work area surfaces is also required. Specific procedures are also given for handling zinc oxide, cadmium selenide, and gold, among other substances.